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  • Title: [Latex Agglutination as an Alternative to the Hemagglutination Reaction of Influenza Viruses].
    Author: Ivanov PA, Lyashko AV, Ionov SA, Shcherbinin DN, Rudneva IA, Shilov AA, Bunkova NI, Shmarov MM, Timofeeva TA.
    Journal: Mol Biol (Mosk); 2023; 57(5):898-906. PubMed ID: 37752655.
    Abstract:
    As an alternative to the classical method of erythrocyte hemagglutination, a latex agglutination assay based on the interaction of influenza viruses with the sialoglycoprotein fetuin immobilized on the surface of polystyrene microspheres has been developed. Twelve influenza A virus strains of different subtypes and two influenza B viruses of different lines were tested. Simultaneous titration of viruses using the classical hemagglutination test and the proposed latex agglutination assay showed similar sensitivity and a high degree of correlation (R = 0.94). The obtained microspheres can be used for titration of viruses that recognize and bind sialylated glycans as receptors. In particular, latex aggregation was also induced by the Newcastle disease virus.
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