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  • Title: Serological analysis of H-2 antigens expression on the cell surface of drug- and lectin-resistant mouse tumor cells.
    Author: Opolski A, Duś D, Radzikowski C.
    Journal: Arch Immunol Ther Exp (Warsz); 1986; 34(1):21-34. PubMed ID: 3778114.
    Abstract:
    The results of studies on the H-2 antigens expression on L1210 and P388 mouse lymphoma cells and their drug-resistant sublines as well as on Lewis lung carcinoma (LL2) cells and their wheat germ agglutinin-resistant variants (LL(2)5 and LL(2)8) are presented. The results revealed no qualitative alterations in H-2 antigens expression on cells of L1210 and P388 leukemias and their drug-resistant sublines. However, as determined by cytotoxic assay the increase relative to parental lines in the expression of normal H-2d antigens on cells of both drug-resistant sublines was observed. Using quantitative absorption assay in addition to differentiate quantitative expression of normal H-2b antigens, the presence of alien H-2k and H-2d specificities on lectin-resistant cells of Lewis lung carcinoma was detected.
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