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  • Title: [Inhibition of ADP-ribosylation by nerve growth factor in the pheochromocytoma PC-12 cell line].
    Author: Kondrat'ev AD, Alakhov VIu, Movsesian VA, Chernyĭ AA, Kaminir LB.
    Journal: Bioorg Khim; 1986 Jun; 12(6):736-40. PubMed ID: 3778531.
    Abstract:
    The effect of nerve growth factor (NGF), purified to homogeneity from bovine seminal plasma using HPLC, on the level of endogenous ADP-ribosylation in pheochromocytoma PC-12 cell line was studied. NGF caused a 30% inhibition of ADP-ribosylation in the cellular homogenate, a 25% inhibition during serum-free cultivation, and a 50% inhibition in the presence of serum in the culture medium. NGF inhibited ADP-ribosylation of several proteins, including a protein with molecular weight of 40,000, probably of membrane origin. A possibility of the interrelation between NGF and cyclase system via receptor-dependent ADP-ribosylation of regulatory components of the adenylate cyclase was discussed.
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