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  • Title: Peri- and postnatal, teratology and reproductive studies of a low molecular weight heparin in rats.
    Author: Bertoli D, Borelli G.
    Journal: Arzneimittelforschung; 1986 Aug; 36(8):1260-3. PubMed ID: 3778563.
    Abstract:
    The low molecular weight heparin (OP/LMWH) used in these studies elicited no evidence of teratogenicity when administered by subcutaneous route during the period of organogenesis to pregnant rats at doses up to 10 mg/kg/d. In reproductive studies there were no effects on conception or pregnancy in males or females rats at dosages up to 10 mg/kg/d (by s.c. route). In these studies the doses were used that in chronic toxicity had shown unremarkable toxic effects on animals. In teratologic and in peri- and postnatal experiments unfractionated heparin at doses of 1 and 10 mg/kg/d by s.c. route was used for comparison.
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