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  • Title: Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice.
    Author: Kawamura T, Singh Mallah G, Ardalan M, Chumak T, Svedin P, Jonsson L, Jabbari Shiadeh SM, Goretta F, Ikeda T, Hagberg H, Sandberg M, Mallard C.
    Journal: ASN Neuro; 2023; 15():17590914231198983. PubMed ID: 37787108.
    Abstract:
    Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD+) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD+ and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves early developmental behavior, as well as motor and memory function.
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