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  • Title: [Increase in the damaging effect of free fatty acids on brain synaptosomes induced by vitamin E deficiency].
    Author: Skrypin VI, Brusovanik VI, Dzhaparidze LM, Erin AN, Selishcheva AA.
    Journal: Biull Eksp Biol Med; 1986 Nov; 102(11):547-9. PubMed ID: 3779076.
    Abstract:
    Using fluorescent probes it has been shown that free fatty acids cause depolarization of synaptosomes isolated from the rat brain. At the same time free fatty acids stimulated 45Ca2+ transport into synaptosomes. It has been demonstrated that synaptosomes isolated from the brain of E-deficient rats were more sensitive to the action of free fatty acids. Depolarization of synaptosomes isolated from the brain of both control and E-deficient rats were reduced by the addition of exogenous alpha-tocopherol.
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