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  • Title: A novel "on-off-on" near-infrared fluorescent probe for Cu2+ and S2- continuous detection based on dicyanoisoflurone derivatives, and its application in bacterial imaging.
    Author: Yao Y, Zeng F, Wu L, Xing S, Yang Q, Li Y.
    Journal: Anal Methods; 2023 Oct 19; 15(40):5329-5340. PubMed ID: 37791492.
    Abstract:
    We have successfully synthesized a near-infrared fluorescent probe for the continuous detection of copper and sulfur ions. The probe has good selectivity and anti-interference ability against Cu2+ and S2-. The results show that after adding Cu2+ to the DL solution of the near-infrared fluorescent probe, Cu2+ forms a [DL + Cu2+] complex with the probe, which leads to fluorescence quenching due to the paramagnetism of Cu2+. The probe can be used for the quantitative detection of Cu2+ with a detection limit of 1.26 × 10-9 M. According to the Job's plot curve the binding stoichiometry between DL and Cu2+ is 1 : 1. Subsequently, S2- was added to the [DL + Cu2+] solution, because the precipitation dissolution equilibrium constant of CuS was Ksp = 1.27 × 10-36, so the binding capacity between Cu2+ and S2- was stronger, CuS precipitation was formed, and red fluorescence was re-released, and the quantitative detection of S2- was realized, and the detection limit was 3.50 × 10-8 M. Through bacterial imaging experiments, we found that the probe can accomplish the fluorescence imaging experiments of Staphylococcus aureus, indicating that the probe has good biopenetration and biocompatibility, and has application prospects in bioimaging and environmental monitoring. In addition, the probe DL has good suitability for Cu2+ and S2- detection in real samples.
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