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  • Title: [Effect of amphotericin B on the sterol composition of Kluyveromyces bulgaricus and Kluyveromyces lactis].
    Author: Coulon J, Hakkou A, Mpona-Minga M, Bonaly R.
    Journal: Can J Microbiol; 1986 Sep; 32(9):738-42. PubMed ID: 3779526.
    Abstract:
    The degree of sensitivity of the yeasts Kluyveromyces bulgaricus and K. lactis to amphotericin B is linked to a difference in the sterol composition of their membranes. No direct proportionality was found between sensitivity and the quantity of sterols present. At sublethal doses, amphotericin B perturbed sterol synthesis, resulting in ergosterol precursor accumulation. An ergosterol pathway is proposed for Kluyveromyces.
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