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  • Title: Detection of thiopentone-reactive IgE antibodies following anaphylactoid reactions during anaesthesia.
    Author: Harle DG, Baldo BA, Smal MA, Wajon P, Fisher MM.
    Journal: Clin Allergy; 1986 Sep; 16(5):493-8. PubMed ID: 3779942.
    Abstract:
    A radioimmunoassay was developed to detect IgE antibodies to the anaesthetic induction agent thiopentone. Significant levels of thiopentone-reactive IgE antibodies were found in the sera of two patients who had experienced life-threatening anaphylactoid reactions following administration of the drug. Inhibition experiments revealed that cross-reactivity occurs between the drug-reactive IgE antibodies and four barbiturate analogues pentobarbitone, phenobarbitone, barbitone and methohexital. The assay should supplement skin testing for the detection of patients with potentially lethal sensitivity to thiopentone.
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