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  • Title: Synthesis, characterization of MOF NiCoZn-LDH@GO on carbon cloth as sensitive and novel nanocomposite applied to electrospun nanofibers network as thin-film microextraction sorbent for detection trace amount of opioid and analgesic drugs from biological fluids.
    Author: Kharazmi F, Hosseini FS, Ebrahimzadeh H.
    Journal: Talanta; 2024 Jan 15; 267():125241. PubMed ID: 37804789.
    Abstract:
    Today, the widespread use of opioid and analgesic drugs (OAs) has caused global concern due to their addictive properties and side effects. Therefore, in this study, polyvinyl alcohol (PVA)/poly acrylic acid (PAA)/MOF NiCoZn-LDH@graphene oxide (GO) electrospun nanofiber was synthesized and employed as an effective and novel sorbent at thin-film microextraction (TF-μSPE) method for the fast and simultaneous extraction of seven opioid and analgesic drugs in human biological fluids (plasma, urine) before performing quantitative analysis by high-pressure liquid chromatography (HPLC-UV) device. This new nano-absorbent was characterized by energy dispersive X-ray spectrometer (EDX), X-ray photoelectron spectroscope (XPS), Fourier transforms infrared spectrometer (FT-IR), field emission scanning electron microscopy (FE-SEM), X-ray diffraction analysis (XRD), and nitrogen absorption-desorption analysis (BET). The combination of MOF NiCoZn-LDH@GO with a highly porous structure and rich functional groups in the PVA/PAA substrate casing significantly improves the absorption properties of the nanofibers. In other words, the existence, of MOF NiCoZn-LDH@GO composite in the polymer network PVA/PAA causes an increase in the extraction efficiency of the electrospinning adsorbent due to the creation of hydrogen bonds and π-π interactions with the intended analytes. Various effective factors in the extraction efficiency of the desired analytes were optimized using a one-variable-at-a-time method. Under the optimum conditions, the linearity dynamic range was achieved in the range of 0.3-1000.0 for caffeine, naloxone, noscapine, and celecoxib, and 0.5-1000.0 μg L-1 for tramadol, codeine, and hydrocodone with correlation coefficients ≥0.999. The lowest detection limit (LODs) and the lowest quantitative limit (LOQs) of the TF-μSPE method were obtained in the range of (0.1-0.15) and (0.3-0.5), respectively.
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