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  • Title: [Thermal sensitivity of Ehrlich ascites cancer cells forming colonies in agar cultures in diffusion chambers].
    Author: Shteĭn LV, Kolesnikova AI, Synzynys BI, Konopliannikov AG.
    Journal: Eksp Onkol; 1986; 8(5):37-40. PubMed ID: 3780508.
    Abstract:
    Thermosensitivity of clonogenic ascites Ehrlich carcinoma cells (AEC), forming colonies in agar cultures in diffusion chambers was studied when heating them in vitro at 41-44 degrees C. The clonogenic cells of AEC are shown not to essentially differ both in the colony-forming efficiency (CFE) and in the proliferative status on the 3rd and 7th days. No essential differences are revealed in thermosensitivity of such cells. The heating time-survival curves are exponential or S-shaped with a small "shoulder". The temperature increase by 1 degree C resulted in a 2-2.5-fold decrease in the time of effective hyperthermia treatment. The values of D0 for cells treated with 42 degrees C in different experiments varied from 20.1 min to 24.6 min. Only one type of thermal damage reaction with the energy of inactivation about 150 kcal/M was observed in AEC cells in the temperature range studied.
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