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  • Title: [Mechanisms of the origination of hypersegmented (hyperdiploid) neutrophils in rats as affected by cyclophosphamide].
    Author: Kozinets GI, Kotel'nikov VM, Berger JJ.
    Journal: Eksp Onkol; 1986; 8(5):52-4. PubMed ID: 3780513.
    Abstract:
    Feulgen cytophotometry has revealed tetraploid DNA content in some hypersegmented mature granulocytes in rat peripheral blood after two weeks of daily injections of cyclophosphamide (20 mg/kg of body weight). In bone marrow of rats which were given the preparation for 7 days myeloblasts, promyelocytes and myelocytes are blocked in G2 phase of the mitotic cycle. About 50% of metamyelocytes, bands and segmented granulocytes are also tetraploid. Thus cyclophosphamide has induced tetraploid hypersegmented neutrophils in rats as a result of maturation of G2 blocked proliferative pool granulocytes.
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