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  • Title: Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene.
    Author: Russell J, Lettieri D, Sherwood LM.
    Journal: Endocrinology; 1986 Dec; 119(6):2864-6. PubMed ID: 3780554.
    Abstract:
    When bovine parathyroid cells in culture are exposed to the active vitamin D metabolite 1,25(OH)2D3, a significant decrease in the steady-state levels of pre-proparathyroid hormone (pre-proPTH) mRNA occurs. The possibility that the fall in specific mRNA is due to a decrease in rate of transcription of the PTH gene was examined in this study. In the presence of 1,25(OH)2D3, there was a rapid and steady decline in PTH gene transcription rate which fell to a minimum of 10-15% of control at 24 h. The effect was observed at physiological levels (10(-11)M) and was also fully reversible.
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