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  • Title: Enhancement of noradrenaline release by 12-O-tetradecanoyl phorbol-13-acetate, an activator of protein kinase C.
    Author: Allgaier C, Von Kügelgen O, Hertting G.
    Journal: Eur J Pharmacol; 1986 Oct 07; 129(3):389-92. PubMed ID: 3780850.
    Abstract:
    12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C (PKC), enhanced the electrically evoked overflow of [3H]noradrenaline in a concentration-dependent manner in rabbit hippocampal slices. 4-O-Methyl-TPA, which lacks the ability to activate PKC had no effect on the evoked tritium overflow. The enhancement of noradrenaline release by TPA was affected by neither the alpha 2-adrenoceptor antagonist yohimbine nor the alpha 2-adrenoceptor agonist clonidine. It is concluded from these results that PKC is involved in the mechanism of stimulus-secretion coupling in noradrenergic nerve terminals of the rabbit hippocampus.
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