These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of sulpiride on amphetamine-induced behaviour in relation to changes in striatal dopamine release in vivo.
    Author: Sharp T, Zetterström T, Ljungberg T, Ungerstedt U.
    Journal: Eur J Pharmacol; 1986 Oct 07; 129(3):411-5. PubMed ID: 3780853.
    Abstract:
    Intracerebral dialysis was used to simultaneously monitor extracellular dopamine (DA) in striatum and behaviour in rats following administration of amphetamine and sulpiride. Amphetamine (2 mg/kg s.c.) caused a marked release of DA into striatal perfusates, an effect which was potentiated in rats pretreated with sulpiride (50 mg/kg s.c.). Amphetamine-induced stereotyped head and forepaw movements were potentiated by sulpiride at a time point corresponding with the enhanced release of DA. In comparison, amphetamine-induced locomotor activity was completely inhibited by sulpiride.
    [Abstract] [Full Text] [Related] [New Search]