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  • Title: Synthesis of some 1-acetylindoline-5-sulphonylamino acid derivatives and studies of their antimicrobial activities.
    Author: Zaher MR, Kora FA, Hussein ME, el-Sayed RA, el-Naggar AM.
    Journal: Farmaco Sci; 1986 Sep; 41(9):729-36. PubMed ID: 3780961.
    Abstract:
    The synthesis of a series of 1-acetylindoline-5-sulphonylamino acids and some of the corresponding methyl esters and hydrazides (II-XXIII) is described. Coupling of 1-acetylindoline-5-sulphonylamino acids with amino acid methyl ester hydrochlorides in THF-Et3N medium, using the dicyclohexylcarbodiimide method gave the desired 1-acetylindoline-5-sulphonyldipeptide methyl esters (XXIV-XXVIII). Most of the synthetic 1-acetylindoline-5-sulphonylamino acid and dipeptide derivatives (II-XXVII) were found to possess various antimicrobial activities against a number of microorganisms.
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