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  • Title: Visualization of Lysosomal Dynamics during Autophagy by Fluorescent Probe.
    Author: Li G, Zhang L, Zheng H, Huang L, Li Z, Li W, Lin W.
    Journal: Anal Chem; 2023 Oct 24; 95(42):15795-15802. PubMed ID: 37815496.
    Abstract:
    Lysosomes are one of the important organelles within cells, and their dynamic movement processes are associated with many biological events. Therefore, real-time monitoring of lysosomal dynamics processes has far-reaching implications. A lysosome-targeted fluorescent probe N(CH2)3-BD-PZ is proposed for real-time monitoring of lysosomal kinetic motility. Using this probe, the dynamic process of lysosomes under starvation induction was successfully explored through fluorescence imaging. Importantly, we observed a new pattern of lysosomal dynamic movement, in which an irregular lysosome was slowly cleaved into two different-sized touching lysosomes and then fused to form a new round lysosome. This research provides a powerful fluorescence tool to understand the dynamic motility of intracellular lysosomes under fluorescence imaging.
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