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  • Title: Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.
    Author: Omura S, Imamura N, Oiwa R, Kuga H, Iwata R, Masuma R, Iwai Y.
    Journal: J Antibiot (Tokyo); 1986 Oct; 39(10):1407-12. PubMed ID: 3781911.
    Abstract:
    A soil isolate named as Micromonospora echinospora subsp. armeniaca subsp. nov. KMR-593 was found to produce at least five related antibiotics, clostomicins, active against Gram-positive bacteria including anaerobes. From the physico-chemical properties, one of these components was identified with lipiarmycin and others were found to be new antibiotics. Each component includes two chlorine atoms and the molecular weights of A and B2, C, and D are 1,058, 1,042 and 1,056, respectively. The structural differences were characterized by NMR analyses.
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