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  • Title: A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma?
    Author: Furst DE, Clements PJ, Graze P, Gale R, Roberts N.
    Journal: Arthritis Rheum; 1979 Aug; 22(8):904-10. PubMed ID: 37843.
    Abstract:
    Six long term survivors of bone marrow transplants developed a syndrome similar to progressive systemic sclerosis (PSS). Cutaneous involvement (6/6), pulmonary disease (6/6), musculoskeletal involvement (4/6), keratoconjunctivitis/positive Schirmer's test (4/6), Raynaud's phenomenon (2/6), and renal and cardiac disease (1/6) were similar to findings in PSS patients. T and B lymphocyte counts and functions were also similar. This PSS-like syndrome, including visceral involvement, after bone marrow transplantation lends support to an immunologic hypothesis of the pathogenesis of progressive systemic sclerosis.
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