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  • Title: Factors influencing in vitro sieving of blood in cerebrovascular accidents. Clinical significance and therapeutic strategy.
    Author: Boisseau MR, Freyburger G, Lorient-Roudaut MF.
    Journal: Klin Wochenschr; 1986 Oct 15; 64(20):1053-7. PubMed ID: 3784456.
    Abstract:
    A haemorheological analysis with measured blood filterability was carried out on 179 patients with cerebrovascular accidents. Reduced blood filterability appeared to be related to the clinical condition: time variation (two phase course), influence of complications and of fatal prognosis. The underlying mechanism of the haemorheological disorders involved three groups of factors: quantitative and qualitative abnormalities of plasma proteins, red cells disturbances and white cells activation, leading to both local and general hyperviscosity, producing a prothrombotic state and a defective microcirculation. The haemorheological treatments are of value to the patients although the relationship between hemodilution and the filterability remains to be exactly defined, as well as a better understanding of the action of the drugs.
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