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  • Title: Influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.
    Author: Csaba G, Szeberényi S, Dobozy O.
    Journal: Med Biol; 1986; 64(4):197-200. PubMed ID: 3784633.
    Abstract:
    A single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome P-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. This suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.
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