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  • Title: Immuno-molecular profile for Biomphalaria glabrata/Schistosoma mansoni interaction.
    Author: Abou-El-Naga IF, Mogahed NMFH.
    Journal: Dev Comp Immunol; 2024 Jan; 150():105083. PubMed ID: 37852455.
    Abstract:
    The complex innate immune defense of Biomphalaria glabrata, the intermediate host of Schistosoma mansoni, governs the successful development of the intramolluscan stages of the parasite. The interaction between the snail and the parasite involves a complex immune molecular crosstalk between several parasite antigens and the snail immune recognition receptors, evoking different signals and effector molecules. This work seeks to discuss the immune-related molecules that influence compatibility in Biomphalaria glabrata/Schistosoma mansoni interaction and the differential expression of these molecules between resistant and susceptible snails. It also includes the current understanding of the immune molecular determinants that govern the compatibility in sympatric and allopatric interactions, and the expression of these molecules after immune priming and the secondary immune response. Herein, the differences in the immune-related molecules in the interaction of other Biomphalaria species with Schistosoma mansoni compared to the Biomphalaria glabrata model snail are highlighted. Understanding the diverse immune molecular determinants in the snail/schistosome interaction can lead to alternative control strategies for schistosomiasis.
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