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  • Title: IgA nephropathy occurring in the context of previous acute glomerulonephritis.
    Author: Yoshizawa N, McClung JA, Ohshima S, Takahashi K, Treser G.
    Journal: Nephron; 1986; 44(3):167-73. PubMed ID: 3785480.
    Abstract:
    A 37-year-old female presented with acute onset of glomerulonephritis 10 days following an upper respiratory infection. Serum complement components were depressed and proteinuria exceeded 3.0 g daily. Renal biopsy revealed granular staining of IgG and C3 along the basement membrane as well as small amounts of IgA in a linear pattern. Gradual resolution of symptoms was followed by recrudescent proteinuria 2 years later. Renal biopsy at this time revealed large deposits of IgA in a mesangial staining pattern consistent with a diagnosis of IgA nephropathy. Possible mechanisms for this unusual morphologic transformation include enhanced mesangial permeability as well as mesangial sequestration of an exogenous antigen.
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