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  • Title: Total Synthesis of Antibacterial Macrolide Sorangiolide A.
    Author: Sahana MH, Paul D, Sharma H, Goswami RK.
    Journal: Org Lett; 2023 Nov 03; 25(43):7827-7831. PubMed ID: 37856450.
    Abstract:
    A convergent route for the asymmetric total synthesis of antibacterial macrolide sorangiolide A has been developed for the first time. The key feature of this synthesis includes Krische iridium-catalyzed anti-diastereoselective carbonyl crotylation, Crimmins acetate aldol, Yamaguchi esterification, Julia-Kocienski olefination, Horner-Wadsworth-Emmons olefination, and ring-closing metathesis. The origin of the low intensity of the 13C{1H} NMR signals of the C1 and C2 centers of the natural product has been investigated, disclosing possible forms of existence for the natural product in the solution phase.
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