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  • Title: Effect of dantrolene sodium on the incidence of seizures in children with spasticity.
    Author: Nogen AG.
    Journal: Childs Brain; 1979; 5(4):420-5. PubMed ID: 378580.
    Abstract:
    In this two-phase study, 21 pediatric patients with epilepsy and spasticity were initially treated with dantrolene sodium suspension and, after a washout period, began a double-blind portion where one half received dantrolene sodium suspension and the other half received a placebo suspension. The frequency of seizures, serum anticonvulsant levels and electroencephalograms were compared with control values. On dantrolene sodium suspension, there was no persistent change in these parameters. Therefore, it is concluded that dantrolene sodium does not adversely affect the frequency of seizures in children with epilepsy and spasticity, who are being maintained on anticonvulsant medications.
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