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  • Title: IgE in patients with glomerulonephritis and minimal-change nephrotic syndrome.
    Author: Schulte-Wissermann H, Görtz W, Straub E.
    Journal: Eur J Pediatr; 1979 May 18; 131(2):105-11. PubMed ID: 378666.
    Abstract:
    Serum levels of IgE were studied in 30 children with minimal-change nephrotic syndrome and 32 children with mesangioproliferative glomerulonephritis during different stages of the disease and treatment. In addition, tissue obtained by renal biopsy was investigated by immunofluorescence histology; no deposits of IgE could be found. The serum IgE levels, however, were increased, particularly in patients with minimal-change nephrotic syndrome. It is concluded that IgE does not play a pathogenic role in the development of the renal disease, but that increased IgE levels are an indication of a disturbance of the immune system.
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