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  • Title: Large-needle thyroid biopsy: still necessary.
    Author: Broughan TA, Esselstyn CB.
    Journal: Surgery; 1986 Dec; 100(6):1138-41. PubMed ID: 3787471.
    Abstract:
    Fine-needle aspiration and large-needle biopsy allow 87% of patients with nodular thyroid disease to avoid operation. We have been concerned that fine-needle aspiration used alone will miss a significant number of follicular neoplasms. Between January 1980 and April 1985, 46 patients had fine-needle aspiration, large-needle biopsy, and thyroidectomy, and the preoperative biopsy specimens suggested or the postoperative pathologic findings confirmed a follicular neoplasm. Seventeen patients had a thyroid carcinoma. All 17 patients also had hypercellular large-needle biopsies, but only nine of these patients had a fine-needle aspiration suspicious of malignancy (p = 0.0078). The inability of fine-needle aspiration to detect a significant number of thyroid cancers emphasizes the need to concomitantly perform large-needle biopsies in all acceptable cases.
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