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  • Title: Photoinduced Palladium-Catalyzed Regio- and Chemoselective Elimination of Primary Alkyl Bromides: A Mild Route to Synthesize Unactivated Terminal Olefins.
    Author: Yang S, Hu H, Chen M.
    Journal: Org Lett; 2023 Nov 10; 25(44):7968-7973. PubMed ID: 37888796.
    Abstract:
    Presented is a highly efficient method for visible-light-induced regio- and chemoselective elimination of alkyl halides yielding unactivated terminal olefins vital in organic synthesis. Achieved through ligand control, the reaction exhibits remarkable regioselectivity and suppresses undesired side reactions, particularly 1,5-hydrogen atom transfer (HAT). The process favors primary alkyl halides while preserving secondary and tertiary alkyl bromides, thereby enabling the incorporation of terminal olefins in complex molecules for late-stage functionalization.
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