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  • Title: Alterations in the lipids and prostaglandins in mouse spleen following the ingestion of menhaden oil.
    Author: Lokesh BR, Hsieh HL, Kinsella JE.
    Journal: Ann Nutr Metab; 1986; 30(6):357-64. PubMed ID: 3789656.
    Abstract:
    Two groups of male mice were fed for 2 weeks with a semisynthetic diet supplemented with either 10% hydrogenated coconut oil or 10% menhaden oil. The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally replaced arachidonic acid in the phospholipids. The synthesis of 6-keto prostaglandin F1 alpha and prostaglandin E2 by spleen tissues were significantly depressed (70-80%) in mice consuming menhaden oil. These studies indicated that n-3 fatty acids can effectively displace arachidonic acid from spleen lipids and thereby affect the synthesis of prostaglandins. The implications of these observations are discussed.
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