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  • Title: Antifertility activity and toxicity of alpha-chlorohydrin aromatic ketal analogues in male rats.
    Author: Brown-Woodman PD, White IG, Ridley DD.
    Journal: Aust J Biol Sci; 1986; 39(2):187-92. PubMed ID: 3789991.
    Abstract:
    The antifertility activity and toxicity of alpha-chlorohydrin and seven aromatic ketal derivatives were investigated in male rats. At a dose of 5 mg/kg injected intraperitoneally each day for 14 days, alpha-chlorohydrin and the methoxy benzaldehyde derivative (compound 2) produced complete infertility. The benzaldehyde derivative (compound 1) was 89% effective and the other five compounds 71-25% effective. All compounds except the least effective antifertility agent, the methylbenzaldehyde derivative (compound 3), reduced the motility of sperm recovered from the epididymis. None of the compounds caused a decrease in body or testes weight but some increased adrenal weight.
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