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  • Title: Theoretical prediction and experimental measurement of the bile-pigment isomer pattern obtained from degradation of catalase haem.
    Author: Brindle NJ, North AC, Brown SB.
    Journal: Biochem J; 1986 May 15; 236(1):303-6. PubMed ID: 3790079.
    Abstract:
    Degradation in vitro of the haem in catalase by a 'coupled oxidation' reaction yields products in which approx. 45% of the haem groups have been cleaved at the alpha-methene bridge, 55% at the beta-bridge and a trace at the delta-bridge. Molecular-mechanics calculations with the three-dimensional structural co-ordinates of catalase shows that these proportions of products can be accounted for by the relative accessibility of the four methene bridges to a haem-linked oxygen molecule, thus further confirming Brown's [(1976) Biochem. J. 159, 23-27] hypothesis that the first stage of haem catabolism in vivo is selective attack by haem-bound oxygen, with selectivity conferred by the surrounding protein moiety.
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