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  • Title: The membrane effect of 1-anilino-8-naphthalene sulfonate on transferrin and iron uptake by rabbit reticulocytes.
    Author: Chan RY, Morgan EH, Loh TT.
    Journal: Biochem Int; 1986 Sep; 13(3):409-15. PubMed ID: 3790137.
    Abstract:
    Studies on the effect of 1-anilino-8-naphthalene sulfonate on uptake of transferrin and iron by rabbit reticulocytes show that the inhibitory action of ANS is localized at the membrane level. The intravesicular pH and cellular ATP level were not affected by this anionic probe. ANS shifted the transition temperature and reduced the enthalpy changes of iron uptake by rabbit reticulocytes. These suggested that the drug reduced the membrane fluidity. Hence, ANS disturbed the physicochemical environment of the receptor for transferrin resulting in the perturbation of receptor-mediated endocytosis.
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