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  • Title: Efficacy of tolciclate solution in patients with tinea pedis.
    Author: Gomez EC, Huntley AC, Isseroff R, Tanji J.
    Journal: Clin Ther; 1986; 8(6):694-9. PubMed ID: 3791364.
    Abstract:
    Forty patients with tinea pedis were treated for six weeks in a double-blind study with a tolciclate or placebo solution. The tolciclate solution demonstrated moderate efficacy compared with placebo. The finding of positive KOH preparations in a significant number of tolciclate-treated patients with persistently negative cultures suggests that the vehicle used (polyethylene glycol-400) may not provide adequate penetration of this effective antifungal agent. No adverse effects were noted.
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