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  • Title: A novel system: 2H-pyrido[3,2-e]-1,2-thiazine-1,1-dioxide. Synthesis and properties of some derivatives.
    Author: Zawisza T, Malinka W.
    Journal: Farmaco Sci; 1986 Oct; 41(10):819-26. PubMed ID: 3792541.
    Abstract:
    A rearrangement of 2H-2-acetonyl(phenacyl)-4,6-dimethyl- pyrido[3,2-d]isothiazoline-3-one-1,1-dioxides (I), (II) to derivatives of the unknown system of 2H-pyrido[3,2-e]-1,2-thiazine-1,1-dioxide (V), (XIII) is described; the synthesis of 2-N-substituted derivatives (VI - XII), (XIV - XVI) is also given. The structures of the new compounds were confirmed with elemental analyses and spectral data (I.R., N.M.R., MS). Some of the newly obtained compounds showed strong analgesic activity upon pharmacological screening.
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