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  • Title: Conformations of cyclic octapeptides. 4. Diastereomers of cyclo(Gly-Pro-Phe-Ala-Asn-Ala-Val-Ser).
    Author: Vishwanath CK, Go A, Parameswaran KN, Wang YS, Kopple KD.
    Journal: Int J Pept Protein Res; 1986 Oct; 28(4):428-36. PubMed ID: 3793373.
    Abstract:
    Stereoisomers of cyclo(Gly-Pro-Phe-Ala-Asn-Ala-Val-Ser) were synthesized. NMR studies of their solution conformations, focusing on peptide N-H solvent exposure, were made. These indicated that a single proline residue in the cyclic octapeptide ring is insufficient constraint to stabilize the backbone conformations that were previously established for cyclo(Gly-Pro-Phe-Ala)2.
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