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  • Title: Cholangiocarcinoma Surveillance Recommendations in Patients with Primary Sclerosing Cholangitis.
    Author: Saca D, Flamm SL.
    Journal: Clin Liver Dis; 2024 Feb; 28(1):183-192. PubMed ID: 37945159.
    Abstract:
    Cholangiocarcinoma (CCA) is a deadly complication observed in the setting of primary sclerosing cholangitis (PSC). When symptoms develop and CCA is diagnosed, it is usually at an advanced stage. Median survival is less than 12 months. Early identification of CCA leads to improved outcomes. Although diagnostic tests have excellent specificity, they are plagued by low sensitivity. No surveillance strategies have been widely agreed upon, but most societies recommend measurement of serum carbohydrate antigen 19-9 and MRCP every 6 to 12 months in patients with PSC. Advances in understanding of the genetic factors that lead to CCA are awaited.
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