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  • Title: Non-cross-reactivity of antibodies to murine LDH-C4 with LDH-A4 and LDH-B4.
    Author: Liang ZG, Shelton JA, Goldberg E.
    Journal: J Exp Zool; 1986 Dec; 240(3):377-84. PubMed ID: 3794626.
    Abstract:
    The induction of infertility by immunization with the sperm-specific lactate dehydrogenase, LDH-C4, suggests its use in a contraceptive vaccine. Development of an immunological contraceptive for human use, however, requires that there be no cross-reactions with somatic tissues. We have demonstrated, using enzyme-linked immunoabsorbence, solid-phase radioimmunoassay, and competitive inhibition radioimmunoassay, that antisera to LDH-C4 is specific and does not cross-react with the somatic isozymes, LDH-A4 and LDH-B4.
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