These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lysis of the glomerular basement membrane in children with IgA nephropathy and Henoch-Shönlein nephritis.
    Author: Yoshikawa N, Yoshiara S, Yoshiya K, Matsuo T, Okada S.
    Journal: J Pathol; 1986 Oct; 150(2):119-26. PubMed ID: 3794864.
    Abstract:
    An electron-microscopic study of the glomerular basement membrane was made on 242 renal biopsies from 222 children with a variety of renal diseases. Lysis of the basement membrane was observed in 16 of the 25 children with Henoch-Schönlein nephritis, 36 of the 72 with IgA nephropathy and one with acute poststreptococcal glomerulonephritis. Lysis was frequently associated with subepithelial dense deposits and polymorphonuclear leukocytes, and these are thought to play a role in the lytic process. There was a significant correlation between the presence of lysis of the basement membrane, the degree of proteinuria and the severity of glomerular changes by light microscopy. These findings suggest that the degree of lysis is an indication of the severity of the disease and lysis is associated with progressive disease and a worse prognosis in Henoch-Schönlein nephritis and IgA nephropathy.
    [Abstract] [Full Text] [Related] [New Search]