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  • Title: A bimetallic organic framework based fluorescent aptamer probe for the detection of zearalenone in cereals.
    Author: Zhu L, Liu W, Tong F, Zhang S, Xu Y, Hu Y, Zheng M, Zhou Y, Zhang Z, Li X, Liu Y.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2024 Feb 05; 306():123628. PubMed ID: 37950933.
    Abstract:
    In this work, a bimetallic organic framework (Cu/UiO-66) based "turn on" fluorescent aptamer probe was designed for the high-efficiency detection of zearalenone (ZEN). In the probe, the 6-carboxyfluorescein-labeled aptamer (FAM-Apt) was used as the recognition element, and the electrostatic interaction, coordination effect, and photoinduced electron transfer effect between FAM-Apt and Cu/UiO-66 caused fluorescence quenching. When ZEN existed, FAM-Apt recognized ZEN specifically, causing FAM-Apt to separate from the surface of Cu/UiO-66 and recovery of fluorescence. Under the optimal conditions, the probe had a linear detection range of 0.5 ng/mL-60 ng/mL, and the detection limit was 0.048 ng/mL. The application potential of the probe was verified by real detection of various cereals and their products, with a standard recovery from 83.67 %-106.8 %. The development of this efficient, rapid, and sensitive ZEN detection method provides a new platform for the quality control of cereals and their products.
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