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  • Title: Neuroimaging manifestations of paediatric histiocytoses.
    Author: Tan HEI, Lakshmanan R, Warne R, Walwyn T, Roebuck D.
    Journal: J Med Imaging Radiat Oncol; 2023 Nov 14; ():. PubMed ID: 37964685.
    Abstract:
    Histiocytoses are rare multi-system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans-related (L), cutaneous (C), malignant (M), Rosai-Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK-positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), Rosai-Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features.
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