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  • Title: Brain and brain monoamine oxidase in aging and in dementia of Alzheimer's type.
    Author: Oreland L, Gottfries CG.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 1986; 10(3-5):533-40. PubMed ID: 3797686.
    Abstract:
    Brain MAO-B activity increases with age. The rate of increase varies in different brain regions. Brain MAO-A activity does not change with age in man and is decreased in the rat. Brain MAO-B activity in AD/SDAT is higher than in age-matched controls. The increased MAO-B activity in aging is due to an increased concentration of otherwise unchanged extrasynaptosomal MAO-B. The increase in brain MAO-B activity with age and in AD/SDAT is more pronounced in white matter than in gray matter. Platelet MAO is increased in patients with AD/SDAT.
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