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  • Title: case of autoimmune GFAP astrocytopathy with eosinophils in the cerebrospinal fluid.
    Author: Lowe MC, Money KM, Matthews E, Pastula DM, Piquet AL.
    Journal: J Neuroimmunol; 2023 Dec 15; 385():578249. PubMed ID: 37992587.
    Abstract:
    Cerebrospinal fluid (CSF) eosinophilia is associated with a narrow differential, primarily including parasitic and fungal infections, neoplasm, and chemical meningitis. It has rarely been reported in neuroinflammatory conditions including as a finding of CSF cytology in two autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy cases. Here we describe a case of autoimmune GFAP astrocytopathy with classic clinical and radiographic features as well as presence of eosinophils in the CSF. This case highlights a potential association of eosinophils in the CSF with autoimmune GFAP astrocytopathy, which may suggest its inclusion in the differential diagnosis of eosinophilic meningitis, encephalitis, or myelitis.
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