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  • Title: Determination of extrinsic pathways of adrenergic nerves to the guinea-pig trachealis muscle using surgical denervation and organ-bath pharmacology.
    Author: Smith RV, Satchell DG.
    Journal: Agents Actions; 1986 Oct; 19(1-2):48-54. PubMed ID: 3799373.
    Abstract:
    Intraluminal pressure changes were recorded in an isolated tracheal tube during electrical stimulation of the recurrent laryngeal nerve or transmural stimulation of the extra-thoracic trachealis muscle. The recurrent laryngeal nerve contained adrenergic nerve fibres running both anteriorly and posteriorly along this nerve and they caused an adrenergic inhibitory response of the trachealis muscle. The superior cervical ganglion was the source of the majority of the adrenergic fibres running both anteriorly and posteriorly within the recurrent laryngeal nerve. The antero-posterior adrenergic fibres reached the recurrent laryngeal nerve via an anastomosis with the superior cervical ganglion. The postero-anterior adrenergic fibres reached the recurrent laryngeal nerve via the vagus nerve, as ipsilateral vagotomy markedly reduced the inhibitory response of the trachealis muscle which had been due to the postero-anterior adrenergic fibres. Superior cervical ganglionectomy caused a significant reduction in the adrenergic response as a percentage of the total inhibitory response of the extra-thoracic trachealis muscle following transmural stimulation. The remaining response was due to stimulation of non-adrenergic non-cholinergic fibres and adrenergic fibres from another source.
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