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  • Title: Peanut agglutinin. IV. A tool for studying human mononuclear cell differentiation.
    Author: London J, Perrot JY, Berrih S, Laroche L, Niaudet P.
    Journal: Scand J Immunol; 1979; 9(5):451-9. PubMed ID: 379984.
    Abstract:
    Peanut agglutinin (PNA) has previously been shown to be a 'marker' for early T subpopulations in mice. We have investigated whether it could also be used in the study of human mononuclear cells. 50--60% of human thymocytes have binding sites for PNA. When separated on a discontinuous Ficoll gradient, the PNA-positive thymocytes are found preferentially in the layers corresponding to the immunoincompetent cells. In the peripheral blood only 5% of the mononuclear cells are PNA-positive and we have shown that these cells are monocytes. In tonsils 13% of PNA+ cells are found and they are mostly lymphocytes. Thus, PNA is a marker for some T cell subsets present in the thymus and tonsils.
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