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  • Title: Relapse in recurrent unipolar depression.
    Author: Kupfer DJ, Frank E.
    Journal: Am J Psychiatry; 1987 Jan; 144(1):86-8. PubMed ID: 3799845.
    Abstract:
    Treatment of the acute phase of recurrent depression has become both routine and successful in the last decade, but the rates of relapse and recurrence remain a problem. In this study a combined psychopharmacologic/psychotherapeutic approach to the acute and continuation treatment of unipolar depressed patients was used. For 59 patients who completed the continuation phase of treatment, the relapse rate after 8 weeks of recovery was 8.5%. Since other recent studies of recurrent depression have reported relapse rates of 15%-22%, these results suggest that there are advantages in combined treatment.
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