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  • Title: Bis-chalcone Fluorescent Probe for Hydrazine Ratio Sensing in Environment and Organism.
    Author: Yang YS, Wang FN, Zhang YP, Liang YN, Xue JJ.
    Journal: Appl Biochem Biotechnol; 2024 Aug; 196(8):5064-5079. PubMed ID: 38012369.
    Abstract:
    In this paper, four novel hydrazine fluorescent probes X1-X4 with bis-chalcone structure were designed and synthesized. Through the measurement of its optical properties, it is found that it can quickly identify hydrazine, high sensitivity, low detection limit, and good anti-interference ability. The recognition of hydrazine by probes X1-X4 is not affected in the pH range of 4-10, X2 has the highest sensitivity, and the detection limit is as low as 0.336 × 10-7 M. Through Gaussian quantization calculation of probe molecules and their reaction products with hydrazine, it is speculated that the recognition mechanism is the closure of intramolecular charge transfer effect. In addition, the cytotoxicity and imaging of HeLa cells were tested, which showed that probes X1-X4 could be used to detect hydrazine in cells.
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