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  • Title: [Evaluation of the inhibiting action of virazole on the reproduction of the vaccinia virus in tissue culture].
    Author: Chizhov NP.
    Journal: Vopr Virusol; 1979; (3):259-62. PubMed ID: 380162.
    Abstract:
    Experimental data of the evaluation of the antiviral activity of virazole in tissue culture using the fluorescent antibody technique are presented. Administration of virazole in the maintenance medium in a concentration range of 800--6.25 microgram/ml immediately after vaccinia virus adsorption exerts a marked inhibiting effect reducing virus reproduction by 3.1--1.6 1g, respectively. The chemotherapeutic index of the drug is 128. In a one-cycle experiment, virazole in the minimal effective concentration had the same inhibiting effect as metizason in the maximal tolerable concentration.
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