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  • Title: [Quantitative historadioautographic analysis of the cellular proliferation characteristics of the aortic wall in rabbits with experimental atherosclerosis].
    Author: Nagornev VA, Babushkina TG.
    Journal: Biull Eksp Biol Med; 1987 Jan; 103(1):104-6. PubMed ID: 3801635.
    Abstract:
    Aortic intima cell proliferation has been studied in 49 rabbits with progressing experimental hypercholesterolemia, using 3H-thymidine. It has been shown that focal cell proliferation is related to infiltration sites of apo-B lipoproteins and can be observed already at pre-lipid stage of atherogenesis. 4 types of proliferating cells involved in the formation of lipid plaques have been identified: endothelial cells, smooth muscle cells, fibroblasts and macrophages, with the latter predominating in the atherosclerotic plaque cover.
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