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  • Title: Corneal involvement in autosomal dominant coloboma/microphthalmos.
    Author: Pearce WG.
    Journal: Can J Ophthalmol; 1986 Dec; 21(7):291-4. PubMed ID: 3801978.
    Abstract:
    Peripheral corneal opacification in the line of closure of the embryonic fissure associated with hyperopic astigmatism and anisometropic amblyopia was identified in two eyes of two members of a family with isolated autosomal dominant coloboma-microphthalmos. A review of the literature disclosed no previously reported cases. It would appear that the gene for isolated coloboma-microphthalmos can affect the growth and differentiation of mesenchymal cells of neural crest origin, as well as the neuroectodermal tissues of the embryonic fissure.
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