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  • Title: A racial difference in apolipoprotein E allele frequencies between the Japanese and Caucasian populations.
    Author: Eto M, Watanabe K, Ishii K.
    Journal: Clin Genet; 1986 Nov; 30(5):422-7. PubMed ID: 3802561.
    Abstract:
    We have examined the apo E phenotype frequencies in the Japanese population (n = 576, 16-78 years of age). Apo E phenotypes were determined by the rapid flat gel isoelectric focusing method that we previously reported. The apo E phenotype frequencies in the Japanese were 0.3% for E2/2, 6.1% for E3/2, 71.9% for E3/3, 0.7% for E4/2, 19.3% for E4/3 and 1.7% for E4/4. The apo E allele frequencies were 0.037, 0.846 and 0.117 for the epsilon 2, epsilon 3 and epsilon 4 alleles, respectively. These frequencies were compared with those in the Caucasian populations (n = 3033) reported by Sing & Davignon (1985). There was a significant difference in the apo E phenotype frequencies between the Japanese and Caucasian populations. In addition, a significantly lower frequency of the epsilon 2 and epsilon 4 alleles and a significantly higher frequency of the epsilon 3 allele were found in the Japanese than those reported for the Caucasian populations. It is concluded that there is a racial difference in the apo E allele frequencies between the Japanese and Caucasian populations.
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